Sibutramine 20 GP

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Sibutralean is indicated for the management of obesity, including weight loss and maintenance of weight loss, and should be used in conjunction with a reduced calorie diet. Sibutramine is recommended for obese patients with an initial body mass index.

Sibutralean hydrochloride (HCL) is a selective serotonin and noradrenaline re-uptake inhibitor. Obesity management is the main medical use of sibutramine. This is not a rapid acting drug. In other words, it works rather slow and in a safe manner. This leads to a steady reduction in fat mass. Longer-term results can be maintained. This drug is most effective in conjunction with a low-calorie diet and training program.
Sibutralean reduces body fat via two very distinct and effective mechanisms. Firstly, it suppresses the appetite. Studies have shown people decrease their calorie intake with as much as 1300 calories a day. Secondly, Sibutralean stimulates metabolism and daily caloric expenditure.
Sibutramine has a thermogenic action that happens in the adrenergic system. This happens mainly through the indirect support of beta 3-receptor activation. With Sibutralean we mainly see strong increases in brown adipose tissue thermogenesis (BAT). This increases the body temperature by 0.5 to 1 degree Celsius. As soon as the body temperature increases it is a clear indication that thermogenesis has been triggered. This means that burning is now taking place.

R230

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SKU: GP023

Description

Sibutramine assists with weight-loss by altering neurotransmitters within the brain. Neurotransmitters are chemicals that are produced and released by nerves in order to communicate with other nerves. Released neurotransmitters may attach to other nerves or they may be taken up again by the nerves that release them, a process termed reuptake.

Sibutramine blocks the reuptake of the neurotransmitter’s dopamine, norepinephrine, and serotonin. Blocking the reuptake of neurotransmitters alters the balance of neurotransmitters within the nerve cells and thereby affect nerve function and interaction.

Patients taking this may achieve a 5-10% reduction from their baseline weight. Additionally, sibutramine-assisted weight loss has been accompanied by improvement in blood lipids (e.g, Cholesterol).

After taking the 20 mg tablet of sibutramine in the morning you will get instantly very thirsty. Consequently, make sure you consume as much water as possible when this thirst sets in. Some people fight this thirst. This reduces the positive effects of sibutramine. As you increase your water intake sibutramine better activated.
Fat burning results are more increased. Fighting the thirst without water consumption decreases the appetite suppressing characteristics. People who consumed a lot of water get better results. Therefore, without water uptake you get very hungry late afternoon. When the product wears off you then defeat the object by consuming large amounts of food. With the increase of water late afternoon hunger is not an issue.
Sibutralean affects chemicals in the brain that affect weight maintenance.
Sibutralean is used together with diet and exercise to treat obesity that may be related to diabetes, high cholesterol, or high blood pressure.

Additional information

Chemical Composition

Sibutramine

Strength

20mg

Pack Size

50 Tabs

Laboratory

Genitec Pharma

Dosage Instructions

20mg – 60mg / Day

Side Effects

Sibutramine substantially increases blood pressure and/or pulse rate in some patients. Regular monitoring of blood pressure and pulse rate is required when prescribing sibutramine.

In placebo-controlled obesity studies, sibutramine 5 to 20 mg once daily was associated with mean increases in systolic and diastolic blood pressure of approximately 1 to 3 mm Hg relative to placebo, and with mean increases in pulse rate relative to placebo of approximately 4 to 5 beats per minute. Larger increases were seen in some patients, particularly when therapy with sibutramine was initiated at the higher doses.

Blood pressure and pulse should be measured prior to starting therapy with sibutramine and should be monitored at regular intervals thereafter. For patients who experience a sustained increase in blood pressure or pulse rate while receiving sibutramine, either dose reduction or discontinuation should be considered. Sibutramine should be given with caution to those patients with a history of hypertension and should not be given to patients with uncontrolled or poorly controlled hypertension.

Common side effects
In general, sibutramine is well-tolerated. The most common side effects have been:
Constipation
Inability to sleep
Headache
Dry mouth
Abdominal Pain
Acne
Rash
Chest Pain
Anxiety
Joint Pain
Back Pain
excitation
Depression
Sweating
Dizziness
Drowsiness
Changes in taste
irregular or painful menstrual periods
Flu-like syndrome
Increased cough
Muscle pain
Nausea
Vomiting
Neck pain
Nervousness
Palpitations
Sore throat
Sinus congestion

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