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IGF-1 is a hormone that manages the effects of growth hormone (GH) in your body. Together, IGF-1 and GH promote normal growth of bones and tissues. GH levels in the blood fluctuate throughout the day depending on your diet and activity levels. But IGF-1 levels remain stable

IGF1 is a growth promoting peptide that plays a critical role in our growth and development. It mediates most of the actions of HGH, one of which is skeletal muscle growth and does this by triggering new cell growth, and by stimulating the uptake of nutrients into growing tissues. IGF1 is produced in our bodies when HGH binds to growth hormone receptors in the liver and other tissues. When the liver releases IGF-1 it signals the body to begin to grow. The amount of IGF-1 produced is regulated by insulin, due to insulin’s ability to increase growth hormone receptor expression.

Original price was: R310.Current price is: R279.

SKU: OL098


Insulin-like growth factor 1 (IGF-1 LR3) is a hormone that functions as the major mediator of growth hormone (GH)-stimulated somatic growth, as well as a mediator of GH-independent anabolic responses in many cells and tissues. IGF-1 is a small peptide (molecular weight 7647) that circulates in serum bound to high affinity binding proteins. IGF-1 LR3 is an unusual peptide in this regard since it is more than 99 percent protein-bound.

IGF-1 is synthesized by multiple mesenchymal cell types. As a result, there are two major mechanisms of IGF-1 regulation:

  • IGF-1 that is synthesized in the liver and secreted into the blood is under the control of GH.
  • Autocrine/paracrine IGF-1 is synthesized in peripheral tissues, such as bone. Its synthesis is controlled by GH and by factors that are secreted locally by the surrounding cell types. Some of the secreted autocrine/paracrine IGF-1 enters the systemic circulation. Therefore, understanding the regulation of autocrine/paracrine synthesis of IGF-1 is necessary to interpret changes in serum IGF-1 concentrations.

IGF-1 LR3 exerts its effects via activation of the IGF-1 receptor. This receptor is widely distributed, which enables blood-transported IGF-1 to coordinate balanced growth among multiple tissues and organs. In contrast, autocrine/paracrine IGF-1 can stimulate local, unbalanced growth independently of systemic GH. Examples of this type of growth regulation are wound healing and growth of the contralateral kidney after unilateral nephrectomy.

Additional information

Chemical Composition

Insulin Like Growth Factor



Pack Size

1 Vial


Oxygen Labs

Dosage Instructions

Injected via Subcutaneous injection after a workout at 20 – 40mcg per day with a typical cycle length of 4-6 weeks

Additional Information

Taking growth hormone can impact how the body responds to insulin which controls blood glucose levels. Untreated growth hormone deficiency can lead to high cholesterol and osteoporosis. Although growth hormone injections are relatively safe and effective, there are a few side effects. Fortunately, serious side effects are rare.

Swelling, numbness, and joint and muscle aches and pains are the most common side effects. You may experience these side effects if you’re getting more growth hormone than you need.

If you have these symptoms, talk to the physician immediately to adjust the amount of growth hormone you are taking.

Some possible side effects with IGF-1/LR3 could be:

  • Joint pain
  • Muscle pain
  • Headaches
  • Nausea
  • Hypoglycaemia
  • May be associated with an increased risk of developing a number of common cancers, including lung, breast, colorectal, and prostate

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