Description
Insulin-like growth factor 1 is a hormone that functions as the major mediator of growth hormone (GH)-stimulated somatic growth, as well as a mediator of GH-independent anabolic responses in many cells and tissues. Insulin-like growth factor-1 is a small peptide (molecular weight 7647) that circulates in serum bound to high affinity binding proteins. IGF-1 is an unusual peptide in this regard since it is more than 99 percent protein-bound.
IGF-1 is synthesized by multiple mesenchymal cell types. As a result, there are two major mechanisms of Insulin-like growth factor-1 regulation:
- GF-1 that is synthesized in the liver and secreted into the blood is under the control of GH.
- Autocrine/paracrine IGF-1 is synthesized in peripheral tissues, such as bone. Its synthesis is controlled by GH and by factors that are secreted locally by the surrounding cell types. Some of the secreted autocrine/paracrine Insulin-like growth factor-1 enters the systemic circulation. Therefore, understanding the regulation of autocrine/paracrine synthesis of IGF-1 is necessary to interpret changes in serum Insulin-like growth factor-1 concentrations.
IGF-1 exerts its effects via activation of the Insulin-like growth factor-1 receptor. This receptor is widely distributed, which enables blood-transported Insulin-like growth factor-1 to coordinate balanced growth among multiple tissues and organs. In contrast, autocrine/paracrine IGF-1 can stimulate local, unbalanced growth independently of systemic GH. Examples of this type of growth regulation are wound healing and growth of the contralateral kidney after unilateral nephrectomy.
Dosage Instructions
Injected via Subcutaneous injection after a workout at 20 – 40mcg per day with a typical cycle length of 4-6 weeks
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