Human Chorionic Gonadotropin (HCG) is a naturally occurring hormone found in high levels during pregnancy. In men, it is used to replicate the function of LH, thereby stimulating the testes to produce testosterone and maintain normal testicular size and function. This makes HCG 5000IU especially valuable during post-cycle therapy (PCT), bridging between cycles, or as an ongoing protocol in testosterone replacement therapy (TRT) to prevent testicular shutdown.
It is also medically used to treat hypogonadism and male infertility. In bodybuilding, HCG helps retain fertility, maintain endogenous testosterone production, and avoid symptoms of low testosterone during or after suppressive anabolic cycles.
Benefits
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Stimulates natural testosterone production
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Prevents or reverses testicular shrinkage
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Helps maintain fertility during steroid or TRT use
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Supports libido and mood during PCT or TRT
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Can improve semen volume and quality
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Effective bridge compound during off-cycle periods
Side effects
HCG 5000IU is generally well-tolerated, but potential side effects include:
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Estrogen-related side effects (water retention, mood swings, gynecomastia) due to increased testosterone aromatization
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Injection site irritation
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Headaches or fatigue (rare)
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Desensitization to LH stimulation with excessive long-term use
Using an aromatase inhibitor (AI) such as Arimidex or Nolvadex alongside HCG can help manage estrogen-related effects.
Dosages & Protocol
Dosages for Men:
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During cycle (testicular support): 250–500IU 2–3 times per week
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Post-cycle therapy (PCT):
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1000IU every other day for 2 weeks
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Follow with a SERM like Clomid or Nolvadex
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For fertility support: 1000–2000IU every other day for several weeks (as prescribed)
PLEASE MAKE USE OF OUR PEPTIDE CALCULATOR FOR FURTHER DOSAGE GUIDANCE.
How to administer – reconstitution and injection
Reconstitution:
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Mix the 5000IU vial with 1–2ml of bacteriostatic water
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Inject the water slowly into the vial
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Swirl gently until completely dissolved
Injection:
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Use an insulin syringe (1ml)
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Inject subcutaneously into the abdominal fat
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Dosing reference (if mixed with 1ml):
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250IU = 5 units
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500IU = 10 units
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1000IU = 20 units, and so on
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Storage
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Before reconstitution: Store in a refrigerator or cool, dry place
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After reconstitution: Refrigerate at 2–8°C and use within 30 days
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Do not freeze. Protect from direct sunlight
Half life & detectability
Half-Life: Approximately 3–5 days, allowing for 2–3 injections per week
Detection Time: Detectable in advanced doping panels for up to 10 days or longer after the last injection
For athletes subject to drug testing, it is crucial to consider these detection times to avoid positive tests for banned substances.