Femara 2.5 HD

Images are for illustrative purposes only


Famara 2.5

Letrozole (Femara) is a reversible aromatase inhibitor that is noted as the most potent nonsteroidal AI. It is one of the three most used aromatase inhibitors by steroid users to control side effects related to estrogen as a result of the use of aromatizing steroids (the other two common AIs being Arimidex – nonsteroidal, and Aromasin – steroidal).

Letrozole is a drug that will appeal to users of the most popular aromatizing steroids such as Testosterone, Dianabol and countless others where the development of water retention, high blood pressure and gynecomastia are serious concerns.

Original price was: R410.Current price is: R369.

SKU: HD044


Femara (Letrozole), like many other aromatase inhibitors (AIs) used in conjunction with anabolic steroids, was initially developed for the medical treatment of breast cancer in post-menopausal women. By blocking the production of estrogen in the body, Femara (Letrozole) has been found to effectively reduce the size and progression of breast tumors. In the bodybuilding community, Letrozole has become popular for its ability to reduce estrogen levels and minimize the side effects of anabolic steroids such as water retention and gynecomastia.

The reason it is only used in women of such an age is due to its powerful estrogen blocking ability which would have serious health implications for pre-menopausal women, but for male steroid users it is this trait that makes AIs like Letrozole so appealing as we aim to combat the adverse effects of estrogen when using aromatizing steroids.

Letrozole can lower your overall estrogen levels because it blocks the aromatase enzyme. This contrasts with the other popular category of estrogen control drugs for steroids users, SERMs, which only target very specific areas of the body. This allows Letrozole to combat a wider range of estrogenic side effects caused by steroids, with the two main ones being gynecomastia and water retention.

This will also help prevent the high blood pressure that can come along when excess water retention is not addressed.

Additional information

Chemical Composition




Pack Size

50 Tabs


HD Labs

Dosage Instructions

1.25mg-2.5mg / Day

Even at very low doses Letrozole is a potent drug so you do not require a lot of it to benefit from its full effects. Unlike with many of the other AIs or SERMs you might use as a steroid user where doses are normally higher than those used for medical treatment, with Letrozole we can get away with using a similar dose or even lower than is administered when the drug is used medically.
Letrozole Dosage During Anabolic Steroid Use
Making the mistake of taking too much Letrozole during steroid use will have no benefit and bring about negative effects, like fatigue. So, it’s critical to maintain a sensible dose.
With a medical dose usually around 2.5mg daily, we would look at no higher than that and most of the time even lower. To protect from estrogen related side effects during steroid use a dose of as low as 0.5mg to 1.25mg every two days is often enough for excellent estrogenic related protection for most men.
Only if you are experiencing early signs of gynecomastia would increasing the dose at this time up to 2.5mg per day can potentially even fully reverse the symptoms; but be prepared for a noticeable zap in energy during this time. Once gyno symptoms subside it’s important to reduce your Letrozole dose back down to regular estrogenic protection levels.

Female Letrozole Dosage:
Increased estrogen levels are not anywhere near as great a concern for female steroid users as it is for males. The main reason for using an AI like Letrozole by females would be to mitigate water retention, especially for competitive bodybuilders or physique athletes where this is most important.

In fact, Letrozole is not recommended as a first choice for females due to its potency in reducing estrogen so much, hence why it is not used medically by females who have not gone through menopause. Females who are determined to use this AI are advised to dose at just 0.5mg every other day and gauge results and effects from there.

Letrozole Dosage for Increased Endogenous Testosterone Secretion and PCT:
This AI may have some ability to raise testosterone levels mainly through its ability to reduce estrogen. Both luteinizing hormone and follicle stimulating hormone have shown to be able to be increased by Letrozole and these are essential to the production of testosterone.
So, while a reduction of estrogen is important for bringing about a rise in testosterone levels, this is a fine balance in men and reducing estrogen too low can actually have the opposite effect with testosterone not able to increase to a normal level if estrogen is suppressed too powerfully, which Letrozole has the ability to do.
For this reason, many will choose not to make use of this drug during post cycle therapy at all, in favor of using a SERM like Nolvadex. However, if you find that Letrozole is preferable for you for post cycle therapy use, a low dose similar or lower to that stated above for during your steroid cycle is the only way to reduce the risk of very low estrogen occurring.
Making use of Letrozole alongside Nolvadex, which is a staple in PCT for most men, results in both drugs making the other less effective. Combining these drugs is not recommended for PCT and therefore most people will opt simply to use the better PCT option in the SERM Nolvadex while enjoying the benefits that Letrozole can provide during the steroid cycle only

Effect on Cycle

Letrozole Effects for Gynecomastia and Estrogen Control:
Letrozole is such a powerful AI and so effective at controlling estrogen that some steroid users have reported being able to successfully reverse the effects of gyno when using this drug.

Even so, it is always preferable to try and prevent gyno from rearing its head at all rather than depending on any drug to reverse it; because while some people might have luck with this when using Letrozole, others will find that more advanced gyno is still not reversible without surgery.
Letrozole will reduce the entire circulating levels of estrogen in the body, unlike SERM drugs which will target specific receptors and are most useful for controlling gyno – while Letrozole will also be powerful for controlling water retention which is the other main adverse effect of steroid use that we all want to avoid.
When using Letrozole you can expect your estrogen levels to be reduced considerably as this is the most powerful AI we can access currently. In fact, it could result in your estrogen dropping too low at times (yes, this can be an issue for men as we do require some small amount of estrogen for normal functioning). But during steroid cycle your main aim with an AI is to reduce, minimize and ultimately prevent the estrogenic side effects that are almost certain to come about when using steroids that aromatize.
There are additional benefits to this estrogen controlling power of Letrozole too: because it means you can prevent water retention, your physique will take on a much harder, drier and ripped appearance because you’re not holding on to water. This can make Letrozole particularly useful for competitive bodybuilders who want to eliminate as much fluid retention as possible and Letrozole is the best AI to help with this goal.

Letrozole vs Arimidex for PCT:
Letrozole and Arimidex are very similar compounds. Both are nonsteroidal aromatase inhibitors, and both are favored by anabolic steroid users to prevent estrogenic side effects. Both drugs have a similar side effect risk profile.

Out of these two AIs, Arimidex generally takes the lead as being more widely used by bodybuilders, but this can come down to several factors including availability, cost, and wanting to follow in the path of what friends and online acquaintances might recommend.

While both AIs can help stimulate natural testosterone production, neither are considered by most guys to be the right choice for PCT when used alone; in fact, many people won’t use a powerful AI like Arimidex or Letrozole during PCT at all and instead go for a SERM drug with Nolvadex being a popular choice, alongside Clomid and often HCG as well.
The main reason for this is that Arimidex is very good at lowering estrogen, and Letrozole even more so. They are so powerful at this task that they can result in estrogen levels that are too low even for the male body.
This causes complications in the hormonal balance and will have a negative impact in your natural testosterone recovery; males still need a small amount of estrogen to keep things in balance and since PCT is all about getting your natural hormone function back to normal, continuing with a high estrogen suppression drug like Letrozole or Arimidex after the steroid cycle can make this difficult, if not impossible.
Another issue when considering the use of Letrozole during PCT is that when it is combined with the staple PCT drug of choice for most people, Nolvadex, a negative interaction occurs where the concentrations of drugs counteract each other. This is also an issue when Arimidex is combined with Nolvadex.
This is another reason why combining either of these AIs with a SERM during PCT is not advisable at all – and since a SERM is basically essential for PCT it is going to take priority over either Letrozole or Arimidex. Both AIs offer far more advantages when their use is limited to during your steroid cycle where you can greatly benefit from their powerful anti-estrogen effects during that time.


Common side effects of Femara include:
Hot flashes,
Warmth in your face or chest
Hair loss
Joint/bone/muscle pain
Unusual sweating or night sweats,
As with all types of drugs, the effects that each individual experiences will vary and that means some people will be able to use Letrozole without a single side effect, while others might have one or more adverse reactions to the drug. The good news is that you have a good selection of other drugs available if Letrozole proves problematic for you.
The profile of possible side effects is comparable for Letrozole as the similar AI Arimidex. Fatigue, muscle aches, diarrhea, constipation, and chest pain are noted as specific side effects that Letrozole can experience but this usually applies to women using it long term as a cancer medication.
Most male steroid users who make use of Letrozole tolerate it well when it’s used at the recommended dosages. Many men will experience no noticeable side effects at all. Taking excessive doses of Letrozole provides an obvious increased risk of serious side effects.
Taking a closer look at some of the possible side effects of Letrozole can help you to be aware of any signs that you might need to lower your dose:
When the Letrozole dose is too high we see a great increased risk of fatigue and this comes about because estrogen levels are reduced too low – men still require some estrogen at low levels to function normally and because Letrozole is so powerful at reducing estrogen, taking too much can lower your levels beyond what is required for the central nervous system to operate normally – bringing on potentially chronic fatigue.

This can be rectified efficiently and easily by reducing your Letrozole dosage until the fatigue subsides as estrogen rises slightly and remaining at the more appropriate dose from then on.

Pain in the Bones or Joints
This side effect is again a result of estrogen reduction going too far which brings about a negative impact on bone mineral content, resulting in the associated pain. While long term use of this drug has a serious risk of decreased bone strength, the short term uses that steroid users will make of Letrozole is unlikely to present the same risks – however if you do experience joint or bone pain it’s another sign that your Letrozole dose is too high. Lowering the dose should eliminate this side effect without any harm done.

A risk that comes with the use of any aromatase inhibitor is a negative impact on cholesterol levels, once again a significantly higher risk if your Letrozole dose is too high. In the cases HDL can lower and LDL can rise – this is the bad cholesterol increasing while the good cholesterol is minimized; exactly the opposite effect that we need.

Estrogen has a beneficial effect on cholesterol so once again we want to maintain as low an effective dose of Letrozole as possible to minimize or eliminate this possible cholesterol related side effect. Various studies on women using Letrozole for cancer treatment mostly show that no long-term impact on cholesterol is noted so this does point to this drug being low risk in terms of adversely affecting your cholesterol health – the negative impacts on cholesterol from some anabolic steroids is of a far greater concern.

Rebound of Estrogen
Unlike some other types of AIs which are known as suicide or non-reversible aromatase inhibitors such as Aromasin, Letrozole is a non-suicidal AI and therefore once you stop using it it’s possible to get a “rebound” in estrogen levels: the sudden halt of the drug’s estrogen reduction effect brings about a bounce in estrogen levels.

For this reason, it is important to slower lower your dose of Letrozole rather than stopping it abruptly. Some people will choose to take a SERM like Nolvadex to provide extra protection during the end of a Letrozole dosage period and mitigate the effects of a possible estrogen rebound at this time.

Shipping & Returns

Looking for a bit more information about how online orders are processed? Here are some commonly asked questions and answers regarding our Online Shop!

How do I know that my order has been received?
When your order has been successfully received by our system, you’ll see a confirmation page. A confirmation e-mail will also be sent to the e-mail address you specified, giving the details of your order. This confirmation indicates that your order has been received. If you can’t find this confirmation email, check your spam or junk mail folders.

Fulfilment of your order may be impacted by stock availability however an email will be forwarded to you once your order is packed and ready for shipping. This email will include tracking details so that you can trace your parcel.

I live outside of South Africa, can I place an order?
Unfortunately, we only deliver to addresses within South Africa at this stage.

I live in South Africa, how much does shipping cost?
Shipping from our Anabolics ZA site is only R 150 nationwide!

When will be delivery arrive?
All orders are sent via a door-to-door courier service. Please make sure that there is someone to receive your order at your nominated address between Monday to Friday, 9:00am-5:00pm. Please note that your order will take 2 – 3 working days from date of payment to arrive. Deliveries to outlying areas may take longer.

Can I make a change or cancel my order after purchasing?
No changes and cancellations are not possible once the order has been processed and an order confirmation screen is displayed.

What is the return policy and process?
Anabolics ZA products are medicines so we cannot refund or accept returns. If you are unsatisfied with your order in any way, please contact us within 30 days of your order via email and we will do our best to resolve your issue.

I have an issue with my order – what do I do next?
Contact us if you have any queries about your order. Refer to your order number as a reference.

Trending Products

Our latest and most popular products