Epistane (2a,3a-epithio-17a-methyl-17b-hydroxy-5a-androstane) is a methylated DHT-derived compound that acts as an anti-estrogenic anabolic agent. It provides users with clean, dry muscle gains, increased strength, and improved muscle definition without the estrogenic side effects seen in traditional steroids. Because it does not convert to estrogen, it helps users achieve a harder, drier physique.
Epistane 10mg is also known for its mild anti-estrogen properties, which can reduce the risk of gynecomastia. It is suitable for both standalone use and as part of a cutting stack. However, due to its 17α-alkylated structure, it is liver toxic and should be run with on-cycle support and followed by a proper PCT.
Benefits
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Promotes dry, lean muscle gains
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Increases strength and muscular hardness
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No estrogenic side effects – no bloating or gynecomastia
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Enhances vascularity and definition
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May have anti-estrogenic effects
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Fast recovery and improved training intensity
Side effects
Epistane 10mg can cause side effects, especially if used at high doses or for extended periods:
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Liver toxicity (17α-methylated) – liver support is required
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Dry joints or joint discomfort (due to lack of water retention)
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Increased blood pressure
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Suppression of natural testosterone production
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Androgenic effects such as acne, hair thinning, or oily skin
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Headaches or lethargy in some users
A full PCT is essential after using Epistane.
Dosages & Protocol
Dosages for Men:
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Beginner: 20–30mg per day
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Intermediate: 30–40mg per day
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Advanced: 40–50mg per day
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Cycle length: 4–6 weeks max due to liver toxicity
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PCT required: Begin immediately after the cycle (Clomid or Nolvadex recommended)
Dosages for Women:
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Not recommended due to high risk of virilization
How to administer
Take orally with water. Split the total daily dosage into 2–3 servings (e.g., morning, afternoon, evening) for best results and reduced side effects. Take with meals to help absorption.
Storage
Store in a cool, dry place away from sunlight and moisture. Keep the container sealed when not in use.
Half life & detectability
Half-Life: Approximately 6–9 hours, requiring multiple daily doses
Detection Time: May be detectable in advanced testing for up to 6–8 weeks after discontinuation
For athletes subject to drug testing, it is crucial to consider these detection times to avoid positive tests for banned substances.