EnClomiphene is a synthetic estrogen clinically administered to help women ovulate. Bodybuilders, (male) following AAS cycles, seeking to jump start natural testosterone production (or those that were simply seeking a natural testosterone spike) have used this drug with great success. EnClomiphene increases activity in the hypothalamus-pituitary-gonadol axis by stimulating the release of more gondotropin from the pituitary gland. Therefore, a higher/faster level of LH (luteinizing hormone) and FSH (follicle stimulating hormone) results. This creates a signal to the leydig cells in the testes which in turn produce more testosterone and sperm. This drug was seldom utilized for longer than 15 days continuously simply due to it being unnecessary.

HCG was combined with Clomiphene (Clomid) sometimes, or Clomiphene was used after HCG administration. This is because EnClomiphene acts by affecting the hypothalamus and pituitary (hypophysis) and regenerating the whole regulating system, while HCG only “imitates” LH, thus stimulating the leydig cells in the testes to produce natural testosterone. (*Also see HCG)

Some may wonder about EnClomiphene being a synthetic estrogen. Yes, it is, but it works as an anti-estrogen. This is due to the fact that Clomiphene has a very low estrogenic effect. This means stronger and more active estrogen, such as those formed during the aromatization of many androgenic steroids, are blocked out of the receptor-site and less estrogenic activity results; less gyno, less water retention. Clomiphene was by no means as effective as Novladex or Proviron for estrogen suppression, but post-cycle it helped greatly.

EnClomiphene  is commonly used by male anabolic steroid users to bind the estrogen receptors in their bodies, thereby blocking the effects of estrogen, i.e., gynecomastia. It also restores the body’s natural production of testosterone. It is commonly used as a “recovery drug” and taken toward the end of a steroid cycle.