Andarine – S4 12.5mg was originally developed to treat muscle wasting conditions and osteoporosis. It works by selectively binding to androgen receptors in muscle and bone tissue, stimulating anabolic activity without significantly affecting other organs. Users report enhanced muscle density, fat reduction, and visual hardness—making S4 a popular option for recomposition and cutting cycles. Unlike anabolic steroids, Andarine is non-methylated and doesn’t convert to estrogen, reducing the risk of water retention or gynecomastia.
One notable side effect is vision alteration (a yellow tint or difficulty adjusting to light), which is dose-dependent and reversible upon discontinuation.
Benefits
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Enhances lean muscle retention
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Promotes fat loss and muscle definition
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Increases strength and vascularity
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Does not aromatize (no estrogenic side effects)
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Short half-life allows for flexible dosing
Side effects
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Visual disturbances (yellow tint, trouble with night vision)
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Mild testosterone suppression
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Possible headaches or fatigue
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No liver toxicity
Dosages & Protocol
For Men
Beginner: 25mg/day = 2 tablets per day (split AM/PM)
Intermediate: 37.5mg/day = 3 tablets per day (split in 3 doses)
Advanced: 50mg/day = 4 tablets per day (2 in AM, 2 in PM)
Cycle Length: 6–8 weeks
Post-cycle therapy (PCT) is recommended after cycles longer than 4 weeks or over 25mg/day.
Not recommended for women due to high chance of virilization.
How to administer
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Take orally with water
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Best taken in split doses (e.g., morning and evening) to maintain stable levels
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Can be taken with or without food
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Do not exceed recommended dose to minimize vision-related side effects
Storage
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Store in a cool, dry place below 25°C
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Keep away from moisture and direct sunlight
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Keep out of reach of children
Half-life & detectability
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Half-life: Approximately 4–6 hours
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Detection time: Up to several weeks
For athletes subject to drug testing, it is important to consider these detection times and plan accordingly to avoid positive tests for banned substances.