Aldara Cream is a topical medication containing the active ingredient imiquimod. It is primarily used to treat certain types of skin conditions, including genital warts (condylomata acuminata), actinic keratosis, and superficial basal cell carcinoma.
1. **Indications**: Aldara Cream is indicated for the treatment of external genital and perianal warts in adults. It is also used for the topical treatment of clinically typical, nonhyperkeratotic, nonhypertrophic actinic keratoses on the face or scalp in adults.
2. **Mechanism of Action**: Imiquimod, the active ingredient in Aldara Cream, is an immune response modifier that stimulates the body’s natural defenses against viruses and abnormal skin growths. It activates toll-like receptor 7 (TLR7) on dendritic cells, leading to the production of interferon-alpha and other cytokines that enhance antiviral and antitumor immune responses.
3. **Dosage and Administration**: Aldara Cream is applied topically to the affected area(s) of the skin, typically once daily before bedtime. The cream should be applied in a thin layer and rubbed gently into the skin until it disappears. Treatment duration and frequency vary depending on the condition being treated and the response to therapy. For genital warts, treatment is usually continued until clearance of warts or for up to 16 weeks. For actinic keratosis, treatment may involve a 2-week application cycle with a 2-week rest period between cycles.
4. **Precautions**: Aldara Cream should not be used on open wounds or irritated skin. It is for external use only and should not be applied internally or near mucous membranes. Patients should avoid sexual contact while the cream is on the skin and should wash their hands thoroughly after application to prevent accidental exposure to other areas of the body or to others. Aldara Cream may cause local skin reactions such as redness, swelling, itching, and burning at the application site.
5. **Monitoring**: Patients using Aldara Cream should be monitored for the development of adverse reactions and for the effectiveness of treatment.
In summary, Aldara Cream is a topical medication used to treat certain skin conditions such as genital warts and actinic keratosis. It works by stimulating the body’s immune response to target abnormal skin growths.