Accutane / Oratane 10mg contains Isotretinoin, a retinoid derived from vitamin A, known for its potent anti-acne effects. Each tablet delivers 10mg of Isotretinoin, which targets severe, treatment-resistant acne by shrinking sebaceous glands, reducing oil production, normalizing skin cell turnover, and decreasing inflammation. It is effective against cystic, nodular, and conglobate acne, preventing permanent scarring and improving skin texture.
The medication works by altering gene expression to reduce sebum output by up to 90%, inhibiting Propionibacterium acnes growth, and preventing comedone formation. Treatment typically lasts 4–6 months, with cumulative doses of 120–150mg/kg body weight achieving long-term remission in 70–80% of patients. Accutane / Oratane 10mg is prescribed for severe acne or moderate acne causing significant psychological distress, often after antibiotics or topical treatments fail. It requires strict medical supervision due to side effects, including teratogenicity, necessitating contraception for women of childbearing age.
Accutane / Oratane 10mg is taken orally, usually once or twice daily with food to enhance absorption. Patients must follow dermatologist guidelines, undergo regular blood tests, and avoid vitamin A supplements or alcohol. Its use is contraindicated in pregnancy, liver disease, or hyperlipidemia, and it is not FDA-approved for non-acne conditions.
Benefits
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Clears severe acne, including cystic and nodular types
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Reduces sebum production and prevents pore clogging
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Minimizes acne scarring and improves skin texture
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Achieves long-term remission in most patients
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Decreases inflammation and bacterial growth
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Improves quality of life for those with persistent acne
Side effects
Despite its benefits, Accutane / Oratane 10mg may cause the following side effects:
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Dry skin, lips, eyes, and mucous membranes (common)
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Elevated liver enzymes or blood lipids, requiring monitoring
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Muscle or joint pain, especially with exercise
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Increased sun sensitivity, risking burns
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Severe birth defects if taken during pregnancy
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Mood changes, including rare risks of depression or suicidal thoughts
These can be managed by moisturizing, using sunscreen, regular blood tests, or consulting a doctor. Women must use two forms of contraception and participate in pregnancy monitoring programs.
Dosages & Protocol
Dosages for Adults and Adolescents (12+):
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Beginner: 0.5mg/kg body weight daily (e.g., 30mg for 60kg person, 3 tablets), taken as 1–2 doses with food
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Intermediate: 0.5–1mg/kg daily (e.g., 30–60mg for 60kg person, 3–6 tablets)
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Take with fatty meals to improve absorption. Typical course: 4–6 months, targeting 120–150mg/kg cumulative dose. Do not exceed 2mg/kg daily. Regular blood tests (liver, lipids) and pregnancy tests (for women) are mandatory.
How to administer – reconstitution and how to inject
Accutane / Oratane 10mg is provided in tablet form and does not require reconstitution or injection.
Administration:
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Swallow tablets whole with a full glass of water
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Take with a fatty meal (e.g., containing dairy or oils) to enhance absorption
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Do not crush or chew tablets, as this may affect efficacy
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Store in a cool, dry place to maintain potency
Storage
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Store at room temperature in a dry place away from light and heat
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Keep packet sealed tightly when not in use
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Avoid exposure to moisture to prevent tablet degradation
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Keep out of reach of children due to teratogenic risks
Half life & detectability
Half-Life: Approximately 21 hours for Isotretinoin, with metabolites persisting up to 50 hours. Detection Time: Detectable in blood for up to 1–2 weeks after last dose, depending on dosage and metabolism. Isotretinoin is not typically banned by WADA but may be monitored in specific contexts.
For athletes subject to drug testing, it is important to consider these detection times and plan accordingly to avoid positive tests for banned substances.
